《大块头有大智慧》剧情简介：

　　Exotic dancer Dai Jet Lo (brawny man) has a gift to see through "cause and consequence". He meets a female cop and uses his gift to help her capture an extremely dangerous murderer. The female cop learns that Dai Jet Lo was once a monk who, due to the murder of a friend, left the monastery to find the killer. The female cop also has a inevitable "karma" that dooms her to die an unnatural death. The duo decide to oppose "cause and consequence" and change what cannot be changed.
　　香港女警李凤仪（张柏芝饰仪）因脱衣舞男大块头（刘德华饰大块头）当众裸露而拘捕之，大块头拒捕逃走，中途遇上重案组警员追捕杀人疑犯，大块头无意间阻挡重案组警员让疑犯逃脱而得罪重案警员被捕。重案组认定大块头跟疑犯有关，对大块头严刑拷问，仪深信大块头跟谋杀案无关，挺身为大块头出头。

　　仪从档案资料中知道大块头原来是持旅游证件的国内人，多年前更是一个和尚，对大块头留下印象。大块头看到仪的心地善良，跟仪说看到重案组警员的冲动，估计追捕疑犯时会两败俱亡，并扬言有办法捉到疑犯以作交换被释放的条件。仪出身自警察世家，父亲和兄长同因捉贼而殉职，仪不想历史重演，逐答应跟大块头一起捉疑凶。原来大块头功夫了得，藉这方面的知识查到死者跟疑凶的关系，终追捕到疑凶归案，仪对大块头产生仰慕。

　　仪欲了解大块头多一点，独自到国内探访大块头出身的寺院，知道大块头的身世----自小便是和尚且具慧根，佛偈和功夫一学便会。多年前大块头的青梅竹马朋友小翠被无辜杀害，曾亲身上山追捕凶手但不果，坐在树下看到“食物链”的生命循环，似有所悟，但自此放弃做和尚的往事，仪对大块头添爱慕之情。

　　仪拼搏追捕入屋行劫的飞天贼而堕楼，大块头及时出现救仪，仪认定大块头对己有情，约会大块头，大块头却失约。仪借找大块头帮忙调查一宗旧案为名，找大块头追问对自己忽冷忽热的原因，大块头坦言说出只是看到仪“业”随身会枉死，但感到仪心地善良，所以才出手救仪，希望为仪化解惜徒劳无功，仪知悉后难以接受。大块头知道那宗旧案就是仪父亲当年遇害的案件，决帮忙。

　　大块头为仪查到杀父凶手原来是一个德高望重的武林宗师，宗师拒捕对仪下毒手，仪重伤垂危……